Detail of Grant Awarded Academic Researches
Identification of conjugative plasmids harboring antibiotic resistance genes in the Tama River flowing through mega city Tokyo
|Affiliation||Graduate School of Integrated Science and Technology, Shizuoka University|
Understanding the mechanism of drug resistance gene transmission by conjugative plasmids is important for preventing the spread of multidrug-resistant bacteria. Exogenous plasmid capturing was performed with microbes in the Tama River. Broad host range plasmids belonging to new types of IncP-1 and PromA groups were successfully obtained. Some IncP-1 plasmids possessed multi-drug resistance genes, including carbapenem-resistance gene. These results suggest that several kinds of plasmids are involved in the spread of antibiotic resistance genes in the Tama river.
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